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KMID : 0384620070180010035
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Korean Journal of Medical Physics
2007 Volume.18 No. 1 p.35 ~ p.41
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Practical Considerations of Arterial Spin Labeling MRI for Measuring the Multi-slice Perfusion in the Human Brain
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Jahng Geon-Ho
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Abstract
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In this work practical considerations of a pulsed arterial spin labeling MRI are presented to reliable multi-slice perfusion measurements In the human brain. Three parameters were considered in this study. First, In order to improve slice profile and Inversion efficiency of a labeling pulse a high power Inversion pulse of adiabatic hyperbolic secant was designed. A 900^{circ} rotation of the flip angle was provided to make a good slice profile and excellent Inversion efficiency. Second, to minimize contributions of a residual magnetization be4ween Interleaved scans of control and labeling we tested three different conditions which were applied 1) only saturation pulses, 2) only spotter gradients, and 3) combinations of saturation pulses and spotter gradients Applications of bo4h saturation pulses and spoiler gradients minimized the residual magnetization. Finally, to find a minimum gap between a tagged plane and an imaging plane we tested signal changes of the subtracted image between control and labeled Images with varying the gap. The optimum gap was about 20mm. In conclusion, In order to obtain high quality of perfusion Images In human brain It Is Important to use optimum parameters. Before routinely using In clinical studios, we recommend to make optimizations of sequence parameters.
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KEYWORD
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Arterial spin labeling, Cerebral perfusion, MRI, Human brain, Optimization
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